产品货号：
GS4908
中文名称：
重组马IFN-γ
英文名称：
Recombinant Equine Interferon -gamma (r EqIFN -γ)
产品规格：
20μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 16.7kDa,a single non-glycosylated polypeptide chain containing 143 amino acids.
储存条件：冷冻（-20℃）
概述
Interferon- gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T -lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN- α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanis ms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.Equine IFN-γ shares 73%~82%amino acid sequence identity with bovine,canine,feline,and porcine IFN-γ and 42%~64%with cotton rat,human,murine,rat,and rhesus macaque IFN-γ.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组马IFN-γ，IFN-γ, Equine，Recombinant Equine Interferon -gamma (r EqIFN -γ)
储存条件：冷冻（-20℃）
概述
Interferon- gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T -lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN- α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanis ms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.Equine IFN-γ shares 73%~82%amino acid sequence identity with bovine,canine,feline,and porcine IFN-γ and 42%~64%with cotton rat,human,murine,rat,and rhesus macaque IFN-γ.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze- dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by an anti - viral assay using human HeLa cells infected w ith encephalomyocarditis(EMC)virus is less than 10.0ng/ml,corresponding to a specific activity of>1.0×105 IU/mg. |
| 成分 | Lyophilized from a 0.2 μ m filtered concen trated solution in 2×PBS,pH 7.4,with 5%trehalose. |
| 内毒素 | Less than 0.1 EU/μ g of rEqIFN -γ as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | QAAFFKEIEN LKEYFNASNP DVGDGGPLFL DILKNWKEDS DKKIIQSQIV SFYFKLFENL KDNQVIQKSM DTIKEDLFVK FFNSSTSKLE DFQK LIQIPV NDLKVQRKAI SELIKVMNDL SPKANLRKRK RSQNPFRGRR ALQ |
相关搜索：重组马IFN-γ，IFN-γ, Equine，Recombinant Equine Interferon -gamma (r EqIFN -γ)